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--- ncbi nlm nih gov pmc articles PMC9030606go drugbank com drugs DB00277For dipyridamole- or regadenoson-induced adverse reactions when aminophylline is not available (eg, due to shortage), theophylline may be used as an alternative Johnson 2011, Singleton 2018 Reversal of adenosine should rarely be required given adenosine's short half-life ASNC [Henzlova 2016] Contraindications--- drugs com cons theophylline-oral html--- ncbi nlm nih gov books NBK519024Reason for the Shortage Major has discontinued theophylline extended-release tablets Teva has had theophylline extended-release tablets temporarily unavailable for several years Theophylline 24-hour extended-release presentations are available from Mylan, Rhodes, and Endo Pharmaceuticals --- atsjournals org doi full 10 1164 rccm 201302-0388PPTheophylline remains one of the most widely prescribed drugs for the treatment of asthma and COPD world-wide, since it is inexpensive and widely available In many industrialized countries, however, theophylline has become a third-line treatment that is only used in poorly controlled patients as an add-on therapy Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction Section: Theophylline is still one of the most widely prescribed drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, because it is inexpensive and widely available Theophylline (dimethylxanthine) occurs naturally in tea and cocoa beans in trace amounts --- ncbi nlm nih gov pmc articles PMC4033977--- medicinenet com theophylline article htmTheophylline is a prescription drug It’s available as an oral solution, an extended-release tablet, and an extended-release capsule It’s also available in an intravenous (IV) form, which is --- healthline com health drugs theophylline-oral-tabletTheophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory diseases, alone or in combination with other drugs The rapid onset of the COVID-19 pandemic urged the development of effective pharmacological treatments to directly attack the development of new variants of the SARS-CoV-2 virus and possess a Theophylline is a medication used to treat asthma and chronic obstructive pulmonary disease as a second-line drug It is a bronchodilator This activity reviews the indications, action, and contraindications for theophylline as a potential agent in treating asthma and chronic obstructive pulmonary disease This activity will highlight the mechanism of action, adverse event profile Theophylline also can be helpful in patients with emphysema and chronic bronchitis when their symptoms are partially related to reversible airway narrowing Theophylline also strengthens right heart function and diaphragm movement Theophylline was approved by the FDA in April 1979 What brand names are available for theophylline? Elixophyllin --- medicine com drug theophylline hcpThis medicine is available only with your doctor's prescription Before using theophylline In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do This is a decision you and your doctor will make For this medicine, the following should be considered: Allergies--- ashp org drug-shortages current-shortages drug-shortage-detail aspx
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