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Also, keep in mind that these medication do not always cause neuropathy, and it is the unique metabolism of certain patients that may cause them to develop neuropathy when prescribed a certain drug The following is a list of drugs that can cause neuropathy in certain patients: Allopurinol Amiodarone Ara-C neuropathyjournal org medication-induced-neuropathyChemotherapy drugs, Metronidazole, Amiodarone, Hydralazine, Enalapril, Phenytoin, Allopurinol, and Colchicine might induce peripheral neuropathy ( 1, 4 ) However, the role of statins in peripheral neuropathy has not yet been definitively proven ( 7 ), and many studies have merely included case reports involving this condition ( 8, 9 ) Statins --- ncbi nlm nih gov pmc articles PMC7365998academic oup com rheumatology article 57 suppl_1 i35 47621051 Introduction Drug-Induced Peripheral Neuropathy (DIPN) occurs when a chemical substance causes damage to the peripheral nervous system [ 1 ] DIPN is potentially irreversible, resulting in sensory deficits and paresthesia typically in a glove and stocking type distribution; motor involvement is rare Abstract A patient experienced an axonomyelinic peripheral neuropathy during a long-term allopurinol treatment The symptoms and signs regressed after drug withdrawal, and the nerve conduction velocities and distal latencies improved The incidence of allopurinol-induced peripheral neuropathy is very low Thus, facilitatory factors have to be sought --- ncbi nlm nih gov pmc articles PMC5942574--- sciencedirect com science article pii S0049017219306900Results: Drug-induced peripheral neuropathy is a common and painful condition caused by many different and frequently prescribed medications Most often, DIPN is seen in chemotherapeutic agents, antimicrobials, cardiovascular drugs, psychotropic, and anticonvulsant drugs Certain drugs exhibit more consistent neuropathic side effects, such as Thank you for your interest in spreading the word about The BMJ NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail --- bmj com content 2 5528 1531 5Alleviation of painful diabetic neuropathy in rats with chronic allopurinol administration has been attributed to inhibition of XO-generated ROS [42] A small human study reported elevated serum XO acitivity in patients with type 2 diabetes with diabetic peripheral neuropathy versus those without disease, providing confirmatory data on the importance of XO in pain syndromes [43] karger com ene article 33 3 193 Regression-of-Allopurinol-lnduced-Peripheralpubmed ncbi nlm nih gov 30666914Allopurinol hypersensitivity syndrome (AHS) is a severe and sometimes life-threatening adverse drug reaction Although AHS is rare, the number of patients with gout requiring allopurinol is high, and there are sufficient overall cases of AHS to warrant consideration of preventive measures Most cases occur within 8–9 weeks of commencing
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